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작성일 2016-10-24 조회수 609
파일첨부 (2016) 1 Normative data for Ad contact heat evoked potentials in adult population- a multicenter study.pdf
제목
(Medoc-Pathway) Normative data for Ad contact heat evoked
Abstract
There has been a significant increase over recent years in the use of contact heat evoked potentials (CHEPs) for the evaluation of
small nerve fiber function. Measuring CHEP amplitude and latency has clinical utility for the diagnosis and assessment of conditions
with neuropathic pain. This international multicenter study aimed to provide reference values for CHEPs to stimuli at 5 commonly
examined body sites. Contact heat evoked potentials were recorded from 226 subjects (114 females), distributed per age decade
between 20 and 79 years. Temperature stimuli were delivered by a thermode (32°C-51°C at a rate of 70°C/s). In phase I of the study,
we investigated side-to-side differences and reported the maximum normal side-to-side difference in Ad CHEP peak latency and
amplitude for leg, forearm, and face. In phase II, we obtained normative data for 3 CHEP parameters (N2P2 amplitude, N2 latency,
and P2 latency), stratified for gender and age decades from face, upper and lower limbs, and overlying cervical and lumbar spine. In
general, larger CHEP amplitudes were associated with higher evoked pain scores. Females had CHEPs of larger amplitude and
shorter latency than males. This substantive data set of normative values will facilitate the clinical use of CHEPs as a rapid,
noninvasive, and objective technique for the assessment of patients presenting with neuropathic pain.
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