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작성일 2016-10-24 조회수 737
파일첨부 (2016) The relationship between hippocampal volume and static postural sway - results from the GAIT study.pdf
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(RM-Biorescue) The relationship between hippocampal volume and static
Abstract The role of the hippocampus in postural control, in particular in maintaining upright stance, has not
been fully examined in normal aging. This study aims to examine the association of postural sway with hippocampal
volume while maintaining upright stance in healthy older individuals. Seventy healthy individuals (mean age
69.7 ± 3.4 years; 41.4 % women) were recruited in this study based on cross-sectional design. Hippocampal volume
(quantified from a three-dimensional T1-weighted MRI using semi-automated software), three center of
pressure (COP) motion parameters (sway area, path length of anterior-posterior (AP) and medial-lateral
(ML) displacement) while maintaining upright stance (eyes open and closed), and the relative difference between
open and closed eye conditions were used as outcome measures. Age, sex, body mass index, lower
limb proprioception, distance vision, 15-item geriatric depression scale score, total cranial volume, and white
matter abnormalities were used as covariates. The sway area decreased from open to closed eye condition but this
variation was non-significant (P = 0.244), whereas path length of AP andML displacement increased significantly
(P < 0.003). Increase in sway area from open to closed eyes was associated with greater hippocampal volume (β
?18.21; P = 0.044), and a trend for an association of increase in path length of AP displacement (P = 0.075 for
open eyes and P = 0.071 for closed eyes) with greater hippocampal volume was reported. The hippocampus is
involved in upright postural control in normal aging, such that an increase in sway area of COPmotion from open to
closed eyes is associated with greater hippocampal volume in healthy older adults.
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