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작성일 2013-08-21 조회수 2262
파일첨부 Edwards et al Pain 2005.pdf
제목
[MEDOC]Quantitative assessment of experimental
Quantitative assessment of experimental pain perception: multiple
domains of clinical relevance
Robert R. Edwards a.*. Eleni Sarlani b. Ursula Wesselmann c. Roger B. Fillingim

1. Introduction
Inter-individual variation in pain perception is substantial(Gracely.1999);thresholdandtoleranceinresponsetoa
variety of painful stimuli are approximately normally
distributed in the general population. These individual
differences are evaluated by administering standardized
noxious stimuli and quantifying pain responses under
controlled laboratory conditions. However. there is little
consensus on whether ?ndings from quantitative sensory
testing (QST). or psychophysical studies of pain. are
relevant to the clinical experience of pain (Gracely. 1999).
Indeed. pain induced by laboratory-administered noxious
stimuli can differ substantially from naturally-occurring
pain along such dimensions as controllability. duration of
stimulation. and range of stimulus intensities. such that the
ascribed meaning of noxious stimulation is rarely comparable
across laboratory and naturalistic settings (Edwards
et al.. 2004). Recently. however. studies demonstrating
alterations in pain perception among many clinical populations
have highlighted the potential value of experimental
pain assessment. or QST (terms which we will use
interchangeably). in understanding chronic pain. Moreover.
scrutinyof thisliterature revealsmultiple domains in which
the clinical relevance of experimental pain assessment has
been repeatedly demonstrated


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